Anthropic appoints first Global Affairs Chief as AI regulation intensifies

Mariano-Florentino Cuéllar will lead Anthropic's global government engagement and regulatory strategy as AI governance, national security concerns and export controls increasingly shape the development and deployment of advanced artificial intelligence technologies.

As governments around the world tighten oversight of artificial intelligence, Anthropic has appointed Mariano-Florentino Cuéllar as its first Chief Global Affairs Officer, signalling a stronger focus on public policy, regulatory engagement and international government relations.

The newly created leadership role comes at a time when AI companies are facing increasing scrutiny over the safety, security and deployment of advanced AI systems. Cuéllar will oversee Anthropic's interactions with policymakers, regulators and government agencies worldwide while helping the company navigate an evolving global regulatory landscape. He will report directly to Anthropic President Daniela Amodei.

Strengthening policy and government engagement

Cuéllar's responsibilities will include managing Anthropic's relationship with the US government as well as engaging with policymakers in international markets where the company is expanding its operations. His role is expected to support the company's compliance with emerging AI regulations while strengthening collaboration with governments on technology governance and public policy.

The appointment reflects the growing importance of policy expertise within AI companies as lawmakers across major economies introduce new frameworks covering AI safety, transparency, national security and responsible innovation.

Cuéllar brings extensive experience from both government and academia. He previously served as a Special Assistant in the administration of former US President Barack Obama and is expected to work closely with the current administration led by President Donald Trump on issues relating to AI policy and regulation.

Appointment comes amid rising AI security concerns

Before joining Anthropic, Cuéllar co-chaired a task force on US national security and nuclear non-proliferation at the Carnegie Endowment for International Peace. He also served as a member of Anthropic's Long-Term Benefit Trust, an independent governance body established to ensure the company remains aligned with its public-benefit mission.

His appointment coincides with growing concerns among governments about the potential misuse of advanced AI technologies, including their application in cyberattacks and other national security risks. These concerns have prompted regulators to impose stricter oversight on frontier AI models and the companies developing them.

Anthropic has also faced increasing regulatory challenges in the United States. Recent export control measures introduced by the Trump administration temporarily limited the company's ability to make its Mythos 5 and Fable 5 AI models available to customers outside the US because of national security considerations. Similar restrictions were also applied to OpenAI's planned release of its GPT-5.6 models.

With regulatory expectations continuing to evolve globally, Anthropic's decision to establish a dedicated global affairs leadership role highlights the increasing intersection of AI innovation, government policy and national security in shaping the future of artificial intelligence.