HPE Supercharges Enterprise AI with NVIDIA Blackwell GPUs, Agentic AI, and Physical AI Innovations

Hewlett Packard Enterprise (HPE) has announced major upgrades to its NVIDIA AI Computing by HPE portfolio, designed to accelerate the adoption of generative AI, agentic AI, and physical AI across industries. The enhancements integrate the latest NVIDIA AI models, NVIDIA Blueprints, and NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs into HPE ProLiant Compute servers and the HPE Private Cloud AI platform. This collaboration strengthens HPE’s position as a leader in AI infrastructure, enabling enterprises to build, train, and deploy next-generation AI applications faster, while ensuring enhanced security, scalability, and productivity.

HPE will ship the ProLiant DL385 Gen11 and DL380a Gen12 Compute servers powered by NVIDIA RTX PRO 6000 Blackwell GPUs, purpose-built for high-performance AI workloads. The DL385 Gen11 supports up to two RTX PRO 6000 GPUs in a compact 2U RTX PRO Server form factor, making it ideal for enterprise data centers with increasing AI demands. The DL380a Gen12, capable of supporting up to eight RTX PRO 6000 GPUs in a 4U configuration, will begin shipping in September 2025 for enterprises seeking maximum AI acceleration. Designed for diverse use cases such as generative AI, robotics, autonomous systems, industrial AI, visual computing, digital twins, and 3D simulation, the Gen12 servers deliver multi-layered security with HPE iLO 7 Silicon Root of Trust, quantum-resistant firmware signing, and secure enclave protection.

“HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI. Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads. With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we’re enabling organizations to embrace the future of AI with confidence and agility, ” said Cheri Williams, Senior Vice President and GM for private cloud and flex solutions, HPE.

The next-generation HPE Private Cloud AI, co-developed with NVIDIA, is set to integrate advanced AI capabilities including NVIDIA Nemotron models for agentic AI reasoning, the Cosmos Reason vision-language model for physical AI and robotics, and the NVIDIA Blueprint for Video Search and Summarization (VSS 2.4) to enable the creation of AI-powered video analytics agents. Through NVIDIA NIM microservices deployed via HPE AI Essentials, enterprises will be able to rapidly develop AI solutions for video intelligence, automated decision-making, and real-time insights while maintaining complete control over their data and ensuring enterprise-grade security.